Dissertations

Inflammation, nutrition and risk of dementia. The Rotterdam Study
Marianne J. Engelhart
(Co)promotor(es): Prof.dr. A. Hofman, dr. M.M.B. Breteler
16 October 2002

Silent brain infarcts. Frequency, risk factors, and prognosis
Sarah E. Vermeer
(Co)promotor(es): Prof.dr. P.J. Koudstaal, Prof.dr. A. Hofman, dr. M.M.B. Breteler
2 October 2002

Determinants of Creutzfeldt-Jakob disease
Esther Croes
(Co)promotor(es): Prof.dr.ir. C.M. van Duijn, Prof.dr. A. Hofman
25 September 2002

Osteoporosis: more than fractures alone
Marjolein van der Klift
(Co)promotor(es): Prof.dr. H.A.P. Pols, Prof.dr. A. Hofman
18 September 2002

A genetic epidemiologic study of hemochromatosis
Omer Njajou Tchikamgoua
(Co)promotor(es): Prof.dr.ir. C.M. van Duijn, Prof.dr. A. Hofman
26 June 2002

Safety aspects of HIV-protease inhibitors
Jeanne P. Dieleman
(Co)promotor(es): Prof.dr. B.H.Ch. Stricker
12 June 2002

Unlicensed and off-label drug use in children
Geert W. 't Jong
(Co)promotor(es): Prof.dr. J.N. van den Anker, Prof.dr. B.H.Ch. Stricker
10 April 2002

Gender differences in cardiovascular disease.
An epidemiologic study of endocrine factors .
Liesbeth Hak
(Co)promotor(es): Prof.dr. H.A.P. Pols, Prof.dr. A. Hofman
13 March 2002

Determinants of primary open-angle glaucoma. A genetic-epidemiologic approach
Caroline A.A. Hulsman
(Co)promotor(es): Prof.dr. P.T.V.M. de Jong, Prof.dr. A. Hofman
6 March 2002

Overanticoagulation on coumarin anticoagulants
Fernie Penning-van Beest
(Co)promotor(es): Prof.dr. B.H.Ch. Stricker, Prof.dr. F.R. Rosendaal
30 January 2002

Epidemiology of diseases

PUBLICATIONS 1^st AUTHOR International scientific publications

Dijk EJ van, Prins ND, Vermeer SE, Koudstaal PJ, Breteler MMB. Frequency of white matter lesions and silent lacunar infarcts.
J Neural Transm Suppl 2002;62:25-39.

Engelhart MJ, Geerlings MI, Ruitenberg A, Swieten JC van, Hofman A, Witteman JCM, Breteler MMB. Diet and risk of dementia: does fat matter?
Neurology 2002;59:1915-21.

Engelhart MJ, Geerlings MI, Ruitenberg A, Swieten JC van, Hofman A, Witteman JCM, Breteler MMB. Dietary intake of antioxidants and risk of Alzheimer's disease: The Rotterdam Study.
JAMA 2002;287:3223-9.

Geleijnse JM, Launer LJ, Kuip DA van der , Hofman A, Witteman JCM. Inverse association of tea and flavonoid intakes with incident myocardial infarction: The Rotterdam Study.
Am J Clin Nutr 2002;75:880-6.

Groot JC de, Leeuwe FE de, Oudkerk M, Gijn J van, Hofman A, Jolles J, Breteler MMB. Periventricular cerebral white matter lesions predict rate of cognitive decline.
Ann Neurol 2002;52:335-41.

Hackert VJ, Heijer T den, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MMB. Hippocampal head size associated with verbal memory performance in non-demented elderly.
Neuroimage 2002;17:1365-72.

Hak AE, Witteman JC, Jong FH de, Geerlings MI, Hofman A, Pols HA. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam Study.
J Clin Endocrinol Meta 2002;87:3632-9.

Heijer T den, Oudkerk M, Launer LJ, Duijn CM van, Hofman A, Breteler MMB. Hippocampal, amygdalar, and global brain atrophy in different apoliprotein E genotypes.
Neurology 2002;59:746-8.

Heijer T den, Vermeer SE, Clarke R, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MMB. Homocysteine and   brain atrophy on MRI of non-demented elderly.
Brain 2002 Jan;126(Pt 1):170-5.

Hollander M, Bots ML, Iglesias del Sol A, Koudstaal PJ, Witteman JCM, Grobbee DE, Hofman A, Breteler   MMB. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction inasymptomatic elderly: The Rotterdam Study.
Circulation 2002;105:2872-7.

Hulsman CAA, Jong PTVM de, Lettink M, Duijn CM de, Hofman A, Bergen AAB. Myocilin mutations in a population-based sample of cases with open-angle glaucoma: The Rotterdam Study.
Graefes Arch Clin Exp Ophthalmol 2002;240:468-72.

Hulsman CA, Houwing-Duistermaat JJ, Duijn CM van, Wolfs R, Borger PH, Hofman A, Jong PT de. Family score as an indicator of genetic risk of primary open-angle glaucoma.
Arch Ophthalmol 2002;120:1726-31.

Hulsman CA, Willemse-Assink JJ, Jong PT de, Lettink M, Sandkuijl LA, Bergen AA. Exclusion of candidate   gene loci for adult onset primary open-angle glaucoma in a genetically isolated population.
Clin Genet 2002;61:160-2.

Iglesias del Sol A, Bots ML, Grobbee DE, Hofman A, Witteman JCM. Carotid intima-media thickness at different sites: relation to incident myocardial infarction.
Eur Heart J 2002;23:934-40.

Ikram MK, Borger PH, Assink JJ, Jonas JB, Hofman A, Jong PT de. Comparing ophthalmoscopy, slide viewing, and semiautomated systems in optic disc morphometry.
Ophthalmology 2002;109:486-93.

Leeuw FE de, Groot CE de, Oudkerk M, Witteman JC, Hofman A, Gijn J van, Breteler MMB. Hypertension and cerebral white matter lesions in a prospective cohort study.
Brain 2002;125:765-72.

Meer IM van der, Maat MP de, Hak AE, Kiliaan AJ, Iglesias del Sol A, Kuip DA van der, Nijhuis RL, Hofman A, Witteman JCM. C-reactive protein predicts progression of atherosclerosis measured at various sites in the arterial tree: The Rotterdam Study.
Stroke 2002;33:2750-5.

Meer IM van der, Maat IP de, Bots ML, Breteler MM, Meijer J, Kiliaan AJ, Hofman A, Witteman JCM. Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study.
Arterioscler Thromb Vasc Biol 2002;22:838-42.

Meer IM van der, Witteman JCM. Apolipoprotein E genotype, smoking and cardiovascular disease.
J Hypertens 2002;20:2327-9.

Oei HH, Vliegenthart R, Hak AE, Iglesias del Sol A, Hofman A, Oudkerk M, Witteman JCM. The association between coronary calcification assessed by electron beam computed tomography and measures of extracoronary atherosclerosis. The Rotterdam coronary calcification study.
J Am Coll Cardiol 2002;39:1745-51.

Penning-van Beest FJ, Gomez Garcia EB, Meer FJ van der, Meegen E van, Rosendaal FR, Stricker BHCh. Levels of vitamin K-dependent procoagulant and anticoagulant proteins in over-anticoagulated patients.
Blood Coagul Fibrinolysis 2002;13:733-9.

Prins ND, Heijer T den, Hofman A, Koudstaal PJ, Jolles J, Clarke R, Breteler MMB. Homocysteine and cognitive function in the elderly: The Rotterdam Scan Study.
Neurology 2002;59:1375-80.

Ruitenberg A, Swieten JC van, Witteman JC, Mehta KM, Duijn CM van, Hofman A, Breteler MMB. Alcohol consumption and risk of dementia: The Rotterdam Study.
Lancet 2002;359:281-6.

The Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke. A meta-analysis.
JAMA 2002;288:2015-23.

Tiemeier H, Tuijl HR van, Hofman A, Meijer J, Kiliaan AJ, Breteler MMB. Vitamin B12, folate, and homocysteine in depression: The Rotterdam Study.
Am J Psychiatry 2002:159:2099-101.

Tiemeier H, Hofman A, Kiliaan AJ, Meijer J, Breteler MMB. Vitamin E and depressive symptoms are not related. The Rotterdam Study.
J Affect Disord 2002;72:79-83.

Tiemeier H, Bakker SLM, Hofman A, Koudstaal PJ, Breteler MMB. Cerebral hemodynamics and depression in the elderly.
J Neurol Neurosurg Psych 2002;73:34-9.

Vermeer SE,   Dijk EJ van, Koudstaal PJ, Oudkerk M, Hofman A, Clarke R, Breteler MMB. Homocysteine,   silent brain infarcts, and white matter lesions: The Rotterdam Scan Study.
Ann Neurol 2002;51:285-9.

Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MMB. Prevalence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study.
Stoke 2002;33:1-5.

Vliegenthart R, Geleijnse JM, Hofman A, Meijer WT, Rooij FJ van, Grobbee DE, Witteman JCM. Alcohol consumption and risk of peripheral arterial disease: The Rotterdam Study.
Am J Epidemiol 2002;155:322-8.

Vliegenthart R, Hollander M, Breteler MMB, Kuip DA van der, Hofman A, Oudkerk M, Witteman JCM. Stroke is associated with coronary calcification as detected by electron-beam CT: The Rotterdam Coronary Calcification Study.
Stroke 2002;33:462-5.

Vliegenthart R, Oudkerk M, Song B, Kuip DA van der, Hofman A, Witteman JCM. Coronary calcification detected by electron-beam computed tomography and myocardial infarction. The Rotterdam Study.
Eur Heart J 2002;23:1596-1603.

PUBLICATIONS CO-AUTHOR International scientific publications

Allam MF, Campbell MJ, Hofman A, del Castillo AS, Navajas RFC. Parkinson's disease and smoking: coherence and plausibility.
Rev Neurol 2002;34:686-9.

Berendschot TT, Willemse-Assink JJ, Bastiaanse M, Jong PT de, Norren D van. Macular pigment and melanin in age-related maculopathy in a general population.
Invest Ophthalmol Vis Sci 2002;43;1928-32.

Degl'Innocenti A, Elmfeldt D, Hansson L, Breteler MMB, James O, Lithell H, Olofsson B, Skoog I, Trenkwalder P, Zanchetti A, Wiklund I. Cognitive function and health-related quality of life in the elderly patients with hypertension - Baseline data from the Study on Cognition and Prognosis in the Elderly (SCOPE).
Blood Pressure 2002;11:157-65.

Schmidt S, Klaver C, Saunders A, Postel E, De La Paz M, Agarwal A, Small K, Udar N, Ong J, Chalukya M, Nesburn A, Kenney C, Domurath R, Hogan M, Mah T, Conley Y, Ferrell R, Weeks D, Jong P de, Duijn CM van, Haines J, Pericak-Vance M, Gorin M. A pooled case-controle study of the apoliprotein E (APOE) gene in age-related maculopathy.
Ophthalmic Genet 2002;23:209-23.

Steinbuch M, D'Agostino RB, Mandel JS, Gabrielson E, McClung MR, Stemhagen A, Hofman A. Assessment of mortality in patients enrolled in a risedronate clinical trial program: A retrospective cohort study.
Reg Toxicol Pharmacol 2002:35:350-6.

Valente EM, Brancati F, Ferraris A, Graham EA, Davis MB, Breteler MMB, Gasser T, Bonifati V, BentivoglioAR, De Michele G, Durr A, Cortelli P, Wassilowsky D, Harhangi BS, Rawal N, Caputo V, Filla A, Meco G, Oostra BA, Brice A, Albanese A, Dallapiccola B, Wood NW. Park6-linked parkinsonism occurs in several european families. Ann Neurol 2002;51:14-8.

Valente EM, Brancati F, Caputo V, Graham EA, Davis MB, Ferraris A, Breteler MMB, Gasser R, Bonifati V, Bentivoglio AR, De Michele G, Dürr A, Cortelli P, Filla A, Meco G, Oostra BA, Brice A, Albanese A, Dallapiccola B, Wood NW and the European Consortium on Genetic Susceptibility in Parkinson's disease. PARK6 is a common cause of familial parkinsonism.
Neurol Sci 2002;23:S117-8.

Plomp AS, Bergen AA, Hulsman CA, Jong PTVM de. Changing perception of hereditary eye diseases.
Ned Tijdschr Geneeskd 2002;146:345-50.

Basic epidemiologic research

PUBLICATIONS 1^st AUTHOR International scientific publications

Bertoli Avella AM, Marcheco Teruel B, Lilibre Riodrigues JJ, Gomez Vierra N, Borrajero Martinez I, Severijnen EA, Joosse M, Duijn CM van, Heredero Baute L, Heutink P. A novel presenilin 1 mutation (L174 M) in al large Cuban Family with early onset Alzheimer disease.Neurogenetics 2002;4:97-104.

Croes EA, Roks G, Jansen GH, Nijssen PC, Duijn CM van. Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone.
J Neurol Neurosurg Psychiatry 2002;72:792-3.

Klift M van der, Pols HA, Geleijnse JM, Kuip DA van der, Hofman A, De Laet CE. Bone mineral density and mortality in elderly men and women: The Rotterdam Study.
Bone 2002:30:643-8.

Klift M van der, Pols HA, Hak AE, Witteman JC, Hofman A, Laet CE de. Bone mineral density and the risk of peripheral arterial disease: The Rotterdam Study.
Calcif Tissue Int 2002;70:443-9.

Klift M van der, Laet CE de, McCloskey EV, Hofman A, Pols HAP. The incidence of vertebral fractures in men and women: the Rotterdam Study.
J Bone Miner Res 2002;17:1051-6.

Laet CE de, Klift M van der, Hofman A, Pols HA. Osteoporosis in men and women: a story about bone mineral density threshold and hip fracture risk.
J Bone Miner Res 2002;17:2231-6.

Njajou OT, Hollander M, Koudstaal PJ, Hofman A, Witteman JCM, Breteler MMB, Duijn CM van. Mutationsin the hemochromatosis gene (HFE) and stroke.
Stroke 2002;33:2363-6.

Njajou OT, Alizadeh BZ, Vaessen N, Vergeer J, Houwing-Duistermaat J, Hofman A, Pols HA, Duijn CM van. The role of hemochromatosis C282Y and H63D gene mutations in type 2 diabetes: findings from the Rotterdam Study and meta-analysis.
Diabetes Care 2002;25:2112-3.

Njajou OT, Vaessen N, Oostra B, Heutink P, Duijn CM van. The hemochromatosis N144H mutation of SLC11A3 gene in patients with type 2 diabetes.
Molec Genet Metab 2002;75:290-1.

Njajou OT, Jong G de, Berghuis B, Vaessen N, Snijders PJ, Goossens JP, Wilson JH, Breuning MH, OostraBA, Heutink P, Sandkuijl LA, Duijn CM van. Dominant hemochromatosis due to N144H mutation of SLC11A3: Clinical and biological characteristics.
Blood Cells Mol Dis 2002;29:439-43.

Njajou OT, Behrooz ZA, Duijn CM van. Genetic screening for common mutations: Lessons from hereditary hemochromatosis.
Eur J Epidemiol 2002;18:3-4.

Roks G, Cruts M, Houwing-Duistermaat JJ, Dermaut B, Serneels S, Havekes LM, Hofman A, Breteler MM, Broeckhoven C van, Duijn CM van. Effect of the APOE-491A/T promotor polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.
Am J Med Genet 2002;114;570-3.

Uitterlinden AG, Fang Y, Bergink AP, Meurs JB van, Leeuwen JPTM van, Pols HAP. The role of vitamin D receptor gene polymorphisms in bone biology.
Mol Cell Endocrinol 2002;197:15-21.

Vaessen N, Janssen JA, Heutink P, Hofman A, Lamberts SW, Oostra BA, Pols HA,   Duijn CM van. Association between genetic variation in the gene for insulin-like growth factor-I and low birth weight.
Lancet 2002;359:1036-7.

Vaessen N, Heutink P, Houwing-Duistermaat JJ, Snijders PJ, Rademaker T, Testers L, Batstra MR, Sandkuijl LA, Duijn CM van, Oostra BA. A genome-wide search for linkage-disequilibrium with type I diabetes in a recent genetically isolated population from the Netherlands.
Diabetes 2002;51:856-9.

Vaessen N, Janssen J, Pols H, Oostra BA, Duijn CM van. Re: Insulin-like growth factor-I genotype and birthweight.
Lancet 2002;360:946.

National scientific publications

Croes EA, Cammen TJ van der, Sleegers K, Duijn CM van. From gene to disease: presenilins and Alzheimer disease.
Ned Tijdschr Geneeskd 2002;146:494-5.

Croes EA, Duijn CM van, Gool WA van, Jansen GH. Ziekte van Creutzfeldt-Jakob: diagnostiek, incidentie, preventie en behandeling.
Ned Tijdschr Geneeskd 2002;146:750-4.

Hottenga JJ, Houwing-Duistermaat JJ, Duijn CM van. Unintentional population stratification in genetic case-control studies.
Ned Tijdschr Geneeskd 2002;146:17-22.

Houben MPWA, Tijssen CC, Duijn CM van, Coebergh JWW. Genetic and epidemiological strategies in the study of glioma etiology.
South West Cancer News 2002;11:9-10.

Pols HAP, Wittenberg J. CBO guideline 'Osteoporosis' (second revision)
Ned Tijdschr Geneeskd 2002;146:1359-63.

PUBLICATIONS CO-AUTHOR International scientific publications

Abel M van, Hoederop JGJ, Dardenne O, St-Arnaud R, Os CH van, Leeuwen JPTM van, Bindels R. 1,25-(OH)2D3-independent stimulatory effect of oestrogen on the expression of EcaC1 in kidney.
J Am Soc Nephrology 2002;13:2102-9.

Arends N, Johnston L, Hokken-Koelega A, Duijn CM van, Ridder M de, Savage M, Clark A. Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).
J Clin Endocrinol Metab 2002;87:2720-4.

Beer F de, Stalenhoef AF, Hoogerbrugge N, Kastelein JJ, Gevers Leuven JA, Duijn CM van, Havekes LM, Smelt AH. Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia.
Arterioscler Thromb Vasc Biol 2002;22:294-9.

Bemd GJ van der, Jhamai M, Staal A, Wijnen AJ van, Lian JB, Stein GS, Pols HAP, Leeuwen JPTM van. A central dinucleotide wihtin vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands.
J Biol Chem 2002;277:14539-46.

Bonifati V, Breedveld GJ, Squitieri F, Vanacore N, Brustenghi P, Harhangi GS, Montagna P, Canella M, Fabbrini CG, Rizzu P, Duijn CM van, Oostra BA, Meco G, Heutink P. Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset.
Ann Neurol 2002;51;253-6.

Bonifati V, Dekker MC, Vanacore N, Fabbrini G, Squitieri F, Marconi R, Antonini A, Brustenghi P, DallaLibera A, De Mari M, Stocchi F, Montagna P, Gallai V, Rizzu P, Swieten JC van, Oostra B, Duijn CM van, Meco G, Heutink P. Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7.
Neurol Sci 2002;23:S59-60.

Budka H, Dormont D, Kretzschmar H, Pocchiari M, Duijn CM van. BSE and variant Creutzfeldt-Jakob disease: never say never.
Acta Neuropathologica 2002;103:627-8.

Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, BarryC, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Duijn C van, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.
Proc Natl Acad Sci U S A 2002;99:13675-80.

Crabtree NJ, Kroger H, Martin A, Pols HA, Lorenc R, Nijs J, Stepan JJ, Falch JA, Miazgowski T, Grazio S, Raptou P, Adams J, Collings A, Khaw KT, Rushton N, Lunt M, Dixon AK, Reeve J. Improving risk assessment: hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. European Prospective Osteoporosis Study.
Osteoporos Int 2002;13:48-54.

Delmas PD, Ensrud KE, Adachi JD, Harper KD, Sarkar S, Gennari C, Reginster JY, Pols HAP, Recker RR, Harris ST, Wu W, Genant HK, Black DM, Eastell R. Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial.
J Clin Endocrinol Metab 2002;87:3609-17.

Dermaut B, Theuns J, Sleegers K, Hasegawa H, Broek M van den, Vennekens K, Corsmit E, St George-Hyslop P, Cruts M, Duijn CM van, Broeckhoven C van. The gene encoding nicastrin, a major gamma-secretase component modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.
Am J Hum Genet 2002;70:1567-74.

Gestel S van, Forsgren T, Claes T, Del-Favero J, Duijn CM van, Sluijs S, Nilsson LG, Aldofsson R, Broeckhoven C van. Epistatic effect of genes from the dopamine and serotonin systems on the temperament straits of novelty seeking and harm avoidance.
Mol Psychiatry 2002;7:448-50.

Havelka S, Uitterlinden AG, Fang Y, Arp PP, Pavelkova A, Vesela M, Halman L, Forejtova S, Ruzickova S, Pavelka K. Collagen type I(alpha 1) and vitamin D receptor polymorphisms in diffuse idiopathic skeletal hyperostosis.
Clin Rheumatol 2002;21:347-8.

Holweg CT, Peeters AM, Balk AH, Uitterlinden AG, Niesters HG, Maat AP, Weimar W, Baan CC. Effect of HLA-DR matching on acute rejection after clinical heart transplantation might be influenced by an IL-2 gene polymorphism.
Transplantation 2002;73:1353-6.

Ismail AA, Pye SR, Cockerill WC, Lunt M, Silman AJ, Reeve J, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, Cannata JB, Cooper C, Delmas PD, Dequeker J, Dilsen G, Falch JA, Felsch B, Felsenberg D, Finn JD, Gennari C, Hoszowski K, Jajic I, Janott J, Johnell O, Kanis JA, Kragl G, Lopez Vaz A, Lorenc R, Lyritis G, Marchand F, Masaryk P, Matthis C, Miazgowski T, Naves-Diaz M, Pols HAP, Poor G, Rapado A, Raspe HH, Reid DM, Reisinger W, Scheidt-Nave C, Stepan J, Todd C, Weber K, Woolf AD, O'Neill TW. Incidence of limb fracture across Europe: results from the European Prospective Osteoporosis Study (EPOS).
Osteoporos Int 2002;13:565-71.

Johnston LB, Arends N, Dahlgren J, Leger J, Czernichow P, Albertsson-Wikland K, Duijn CM van, Hokken-Koelega A, Savage MO, Clark AJ. Gene association studies in small for gestational age infants.
J Pediatr Endocrinol Metab 2002;15:1459.

Kann P, Bergink AP, Fang Y, Daele Pl van, Hofman A, Leeuwen JP van, Beyer J, Uitterlinden AG, Pols HA. The collagen Ia1 SP1 polymorphism is associated with differences in ultrasound transmission velocity in the calcaneus in postmenopausal women.
Calcif Tissue Int 2002;70:450-6.

Kumar-Singh S, Cras P, Wang R, Kros JM, Swieten J van, Lubke U, Ceuterick C, Serneels S, Vennekens K, Timmermans JP, Marck E van, Martin JJ, Duijn CM van, Broeckhoven C van. Dense-core senile plaques in the flemish variant of Alzheimer's disease are vasocentric.
Am J Pathol 2002;161:507-20.

Lebrun CE, Schouw YT van der, Bak AA, Jong FH de, Pols HAP, Grobbee DE, Lamberts SW, Bots ML. Arterial stiffness in postmenopausal women: determinants of pulse wave velocity.
J Hypertens 2002;20:2165-72.

Meijers-Heijboer H, Ouweland A van den, Klijn J, Wasielewski M, Snoo A de, Oldenburg R, Hollestelle A, Houben M, Crepin E, Veghel-Plandsoen M van, Elstrodt F, van Duijn C, Bartels C, Meijers C, Schutte M, McGuffog L, Thompson D, Easton DF, Sodha N, Seal S, Barfoot R, Mangion J, Chang-Claude J, Eccles D, Eeles R, Evans DG, Houlston R, Murday V, Narod S, Peretz T, Peto J, Phelan C, Zhang HX, Szabo C, Devilee P, Goldgar D, Futreal PA, Nathanson KL, Weber BL, Rahman N, Stratton MR. Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations.
Nat Genet 2002;31:55-9.

Rademakers R, Cruts M, Dermaut B, Sleegers K, Rosso SM, Broeck M van den, Backhovens H, Swieten J van, Duijn CM van, Broeckhoven C van. Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval.
Mol Psychiatry 2002;7:1064-74.

Rosso SM, Roks G, Broeckhoven C van, Cruts M, Duijn CM van, Swieten JC van. Apolipoprotein E4 in the temporal variant of frontotemporal dementia.
J Neurol Neurosurg Psychiatry 2002;72:820.

Rossum EF van, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, Grobbee DE, Jong FH de, Duijn CM van, Pols HAP, Lamberts SW. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.
Diabetes 2002;51:3128-34.

Slooter AJC, Roks G, Duijn CM van. Genetic association studies: genes in search of diseases.
Neurology 2002;58:1577.

Sluis IM van der, Hop WC, Leeuwen JPTM van, Pols HAP, Muinck Keizer-Schrama SM de. A cross-sectional study on biochemical parameters of bone turnover and vitamin D metabolites in healthy dutch children and young adults.
Horm Res 2002;57:170-9.

Sluis IM van der, Muinck Keizer-Schrama SM de, Pols HAP, Lequin MH, Krenning EP, Uitterlinden AG. Collagen Ia1 polymorphism is associated with bone characteristics in caucasian children and young adults.
Calcif Tissue Int 2002;71:393-9.

Tryfonidou MA, Stevenhagen JJ, Bemd GJ van den, Oosterlaken-Dijksterhuis MA, DeLuca HF, Mol JA, Brom WE van den, Leeuwen JPTM van, Hazewinkel HA. Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs.
J Nutrition 2002;132:2644-50.

Ward HJ, Everington D, Croes EA, Alperovitch A, Delasnerie-Lauprêtre N, Zerr I, Poser S, Duijn CM van. Sporadic Creutzfeldt-Jakob disease and surgery: A case-control study using community controls.
Neurology 2002;59:543-8.

Weyts FAA, Li Y-S, Leeuwen JPTM van, Weinans H, Chien S. Fluid shear stress induces Shc recruitment to a v b 3 integrin and ERK activation in human osteoblasts.
J Cell Biochem 2002;87:85-92.

Clinical epidemiology

PUBLICATIONS 1^st AUTHOR International scientific publications

Adriaensen M EAPM, Bosch JL, Halpern EF, Hunink MGM, Gazelle GS. Elective endovascular versus open surgical repair of abdominal aortic aneurysms: A systematic review of short-term results.

Radiology 2002;224:739-47.

Bleumink GS, Molen-Eijgenraam M van der, Strijbos JH, Sanwikarja S, Puijenbroek EP van, Stricker BHCh.Pergolide-induced pleuropulmonary fibrosis.

Clin Neuropharmacol 2002;25:290-3.

Bosch JL, Halpern EF, Gazelle GS.   Comparison of preference-based utilities of the Short-Form 36 Health Survey and Health Utilities Index before and after treatment of patients with intermittent claudication.

Med Decis Making 2002;22:403-9.

Bosch JL, Kaufman JA, Beinfeld MT, Adriaensen M EAPM, Brewster DC, Gazelle GS. Abdominal aortic aneurysms: cost-effectiveness of elective endovascular and open surgical repair.

Radiology 2002;225:337-44.

Dieleman JP, Sturkenboom MCJM, Wit FW, Jambroes M, Mulder JW, Veen JH ten, Juttmann J, Stricker BHCh, Lange JMA, Ende ME van der. Low risk of treatment failure after substitution of nevirapine for protease inhibitors among HIV-infected patients with virus suppression.

J Infect Dis 2002;185:1261-8.

Dieleman JP, Sturkenboom MCJM, Jambroes M, Gyssens IC, Weverling GJ, Veen JH ten, Schrey G, Reiss P, Stricker BHCh, for the ATHENA Study Group. Risk factors for urological symptoms in a cohort of users of the HIV protease inhibitor indinavir sulfate: the Athena Cohort.

Arch Intern Med 2002;162:1493-1501.

Dieleman JP, Jambroes M, Gyssens IC, Sturkenboom MC, Stricker BHCh, Mulder WM, Wolf F de, Weverling GJ, Lange JM, Reiss P, Brinkman K. Determinants of recurrent toxicity-driven switches of highly active antiretroviral therapy. The ATHENA Cohort.

AIDS 2002;16:737-45.

Eland IA, Sturkenboom MCJM, Lei J van der, Wilson JHP, Stricker BHCh. Incidence of acute pancreatitis.

Scand J Gastroenterol 2002;37:124.

Feenstra J, Heerdink ER, Grobbee DE, Stricker BHCh. Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure.

Arch Int Med 2002;162:265-70.

Gill-Leertouwer TC, Gussenhoven EJ, Bosch JL, Deinum J, Overhagen H van, Derkx FHM, Pattynama PMT. Predictors for clinical success at one year following renal artery stent placement.

J Endovasc Ther 2002;9:495-502.

Heijenbrok-Kal MH, Hunink MGM. Adjusting for bias in diagnostic reports.

Am J Med 2002;112:322-4.

Hunink MGM, Krestin GPK. Study design for the concurrent development, assessment, and implementation of new diagnostic imaging technology.

Radiology 2002;222:604-14.

Hunink MGM. Presidential Address: Proactive decision making.

Med Decis Making 2002;22:182-6.

Jong GW 't, Linden PD van der, Bakker EM, Lely N van der, Eland IA, Stricker BHCh, Anker JN van den. Unlicensed and off-label drug use in a paediatric ward of a general hospital in the Netherlands.

Eur J Clin Pharmacol 2002;58:293-7.

Jong GW 't, Stricker BHCh, Choonara I, Anker JN van den. Lack of effect of the European guidance on clinical investigation of medicines in children.

Acta Paediatr 2002;91:1233-8.

Jong GW 't, Eland IA, Sturkenboom MCJM, Anker JN van den, Stricker BHCh. Unlicensed and off label prescription of drugs to children: population based cohort study.

Br Med J 2002;324:1313-4.

Jong GW 't, Eland IA, Hoog M de, Sturkenboom MCJM, Anker JN van den, Stricker BHCh. Unlicensed and off-label prescription of systemic anti-infective agents to children.

Paed Perinatal Drug Ther 2002;5:71-7.

Linden PD van der, Sturkenboom MCJM, Herings RMC, Leufkens HGM, Stricker BHCh. Fluoroquinolones and risk of achilles tendon disorders: case-control study.

Br Med J 2002;324:1306-7.

Maitland-van der Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Leufkens HG, Broeckhoven C van, Duijn CM van, Boer A de. The effectiveness of HMG-CoA reductase inhibitors in an elderly population is independent of   apolipoprotein E-genotypes.

Br J Clin Pharmacol 2002;53:548P.

Maitland-van der Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Witteman JC, Breteler MM, Leufkens HG, Duijn CM van, Boer A de. The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitor (statins) in the elderly is not influenced by apolipoprotein E genotype.
Pharmacogenetics 2002;12:647-53.

Maitland-van der Zee AH, Klungel OH, Stricker BHCh, Verschuren WMM, Kastelein JJP, Leufkens HGM, Boer A de. Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors.

Atherosclerosis 2002;163:213-22.

Penning-van Beest FJ, Geleijnse JM, Meegen E van, Vermeer C, Rosendaal FR, Stricker BHCh. Lifestyle and diet as risk factors for overanticoagulation.

J Clin Epidemiol 2002;55:411-7.

Riemsdijk MM van, Ditters JM, Sturkenboom MCJM, Tulen JH, Ligthelm RJ, Overbosch D, Stricker BHCh.Neuropsychiatric events during prophylactic use of mefloquine before travelling. Eur J Clin Pharmacol 2002;58:441-5.

Riemsdijk MM van, Sturkenboom MCJM, Ditters JM, Ligthelm RJ, Overbosch D, Stricker BHCh. Atovaquone plus chloroguanide versus mefloquine for malaria prophylaxis: A focus on neuropsychiatric adverse events.

Clin Pharmacol Ther 2002;72:294-301.

Spronk S, Dolman W, Boelhouwer RU, Veen HF, Hoed PT den. The vascular laboratory in practice: a national survey in the Netherlands.

Eur J Vasc Endovasc Surg   2002;24:300-3.

Stricker BHCh, Hofman A, Breteler MMB. Re: Nonsteroidal drugs and Alzheimer's disease.

N Eng J Med 2002;346:1172-3 .

Sturkenboom MCJM, Romano F, Simon G, Correa-Leite ML, Villa M, Nicolosi A, Borgnolo G, Bianchi-Porro G, Mannino S. The iatrogenic costs of NSAID therapy: a population study.

Arthritis Rheum 2002;47:132-40.

Verhamme KMC, Dieleman JP, Bleumink GS, Lei J van der, Sturkenboom MCJM. Incidence and prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in primary care - The Triumph Project.

Eur Urology 2002;42:323-8.

Visser LE, Graatsma HH, Stricker BHCh. Contraindicated NSAIDs are frequently prescribed to elderly patients with peptic ulcer disease.

Br J Clin Pharmacol 2002;53:183-8 .

Visser LE, Penning-van Beest FJA, Kasbergen AAH, De Smet PAGM, Vulto AG, Hofman A, Stricker BHCh. Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants.

Clin Pharmacol Ther 2002;71:496-502 .

Visser LE, Penning-van Beest FJA, Kasbergen HAA, De Smet PAGM, Vulto AG, Hofman A, Stricker BHCh. Overanticoagulation associated with combined use of antibacterial agents and acenocoumarol or phenprocoumon anticoagulants.

Thromb Haemost 2002;88:705-10.

National scientific publications

Bleumink GS, Stricker BHCh. Moet foliumzuursupplementatie bij methotrexaattherapie op de dag van inname worden gestaakt?

Reumatologen Vademecum 2002;4:1-3.

Bleumink GS, Stricker BHCh. Subacute cutane lupus erythematodes toegeschreven aan het gebruik van etanercept.

Geneesmiddelenbulletin 2002;36:47.

Hooft CS van der, Stricker BHCh. Efedrine en Ephedra in afslankmiddelen en andere producten.

Ned Tijdschr Geneeskd 2002;146:1335-6.

Hooft CS van der, Stricker BHCh. Tranylcypromine en leverenzymstijgingen.

Geneesmiddelenbulletin 2002;36:73.

Hooft CS van der, Garbis JM, Passier JLM, Stricker BHCh. In hoeverre zijn de SSRI's schadelijk voor de ongeboren vrucht?

Apothekers Vademecum 2002;12:1-3.

Hottenga JJ, Houwing-Duistermaat JJ, Duijn CM van. Roaming through methodology. XXXVII. Unintentional population stratification in genetic case-control studies.

Ned Tijdschr Geneeskd 2002;146:17-22.

Stricker BHCh. Geneesmiddelenbewaking in Nederland. Over Machiavelli, Montesquieu en de vogelvrije burger.

Pharm Weekbl 2002;137:552-4.

Stricker BHCh. Geneesmiddelenbewaking: over spookschepen en Russische roulette.

Ned Tijdschr Geneeskd 2002;146:1258-61.

Stricker BHCh. Te veel communicatie, te weinig specialisme.

Conceptuur 2002;31:3.

PUBLICATIONS CO-AUTHOR International scientific publications

Arends N, Johnston L, Hokken-Koelega A, Duijn C van, Ridder M de, Savage M, Clark A. Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).

J Clin Endrocrinol Metab 2002;87:2720.

Arets HG, Kamps AW, Brackel HJ, Mulder PG, Vermue NA, Ent CK van der. Children with mild asthma: do they benefit from inhaled corticosteroids?

Eur Respir J 2002;2:1470-5.

Becker MJ, Marie S de, Fens MH, Hop WCJ, Verbrugh HA, Bakker-Woudenberg IA. Enhanced antifungal efficacy in experimental invasive pulmonary aspergillosis by combination of AmBisome with Fungizone as assessed by several parameters of antifungal response.  

J Antimicrob Chemother 2002;49:813-20.

Beinfeld MT, Bosch JL, Gazelle GS. Hospital costs of uterine artery embolization and hysterectomy for uterine fibroids tumors.

Acad Radiol 2002;9:1300-4.

Berger RM, Cromme-Dijkhuis AH, Hop WCJ, Kruit MN, Hess J. Pulmonary arterial wall distensibility assessed by intravascular ultrasound in children with congenital heart disease: an indicator for pulmonary vascular disease?

Chest 2002;122:549-57.

Beumer A, Swierstra BA, Mulder PG. Clinical diagnosis of syndesmotic ankle instability: evaluation of stress tests behind the curtains.

Acta Orthop Scand 2002;73:667-9.

Boito SM, Laudy JA, Struijk PC, Stijnen T, Wladimiroff JW. Three-dimensional US assessment of hepatic volume, head circumference, and abdominal circumference in healthy and growth-restricted fetuses.

Radiology 2002;223:661-5.

Boito SM, Struijk PC, Ursem NT, Stijnen T, Wladimiroff JW. Umbilical venous volume flow in the normally developing and growth-restricted human fetus.

Ultrasound Obstet Gynecol 2002;19:344-9.

Bonke B, Tibben A, Lindhout D, Stijnen T. Favourable mutation test outcomes for individuals at risk for Huntington disease change the perspectives of first-degree relatives.

Hum Genet 2002;111:297-8.

Braat JP, Mulder PG, Duivenvoorden HJ, Gerth van Wijk R, Rijntjes E, Fokkens WJ. Pollutional and meteorological factors are closely related to complaints of non-allergic, non-infectious perennial rhinitis patients: a time series model.

Clin Exp Allergy 2002;32:690-7.

Broek RW van den, Maassen van den Brink A, Mulder PG, Bogers AJ, Avezaat CJ, John GW, Saxena PR. Comparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteries.

Eur J Pharmacol 2002;443:125-32.

Buljevac D, Flach HZ, Hop WCJ, Hijdra D, Laman JD, Savelkoul HF, Meche FG van der, Doorn PA van, Hintzen RQ. Prospective study on the relationship between infections and multiple sclerosis exacerbations.  

Brain 2002;125:952-60.

Buth J, Marrewijk CJ van, Harris PL, Hop WCJ, Riambau V, Laheij RJ. Outcome of endovascular abdominal aortic aneurysm repair in patients with conditions considered unfit for an open procedure: A report on the EUROSTAR experience.

J Vasc Surg 2002 35:211-21.

Cavelaars M, Tulen JH, Bemmel JH van, Borg MJ ter, Mulder PG, Meiracker AH van den. Determinants of ambulatory blood pressure response to physical activity.

J Hypertens 2002;20:2009-15.

Damen L, Stijnen T, Roebroeck ME, Snijders CJ, Stam HJ. Reliability of sacroiliac joint laxity measurement with Doppler imaging of vibrations.

Ultrasound Med Biol 2002;28:407-14.

Delden PG van, Houweling PL, Bencini AF, Ephraim EP, Frietman RC, Niekerk J van, Stolk MA van, Verheijen R, Wajer OJ, Mulder PG. Remifentanil-sevoflurane anaesthesia for laparoscopic cholecystectomy: comparison of three dose regimens.

Anaesthesia 2002;57:212-7.

Devillers AC, Waard-van der Spek FB de, Mulder PG, Oranje AP. Treatment of refractory atopic dermatitis using 'wet-wrap' dressings and diluted corticosteroids: results of standardized treatment in both children and adults.

Dermatology 2002;204:50-5.

Doorn WJ van, ten HB,   Biezen FC van, Hop WCJ, Ginai AZ, Verhaar JA. Migration of the femoral stem after impaction bone grafting. First results of an ongoing, randomised study of the exeter and elite plus femoral stems using radiostereometric analysis.

J Bone Joint Surg Br 2002;84:825-31.

El Azab SR, Rosseel PM, Lange JJ de, Wijk EM van, Strik R van, Scheffer GJ. Effect of VIMA with sevoflurane versus TIVA with propofol or midazolam-sufentanil on the cytokine response during CABG surgery.

Eur J Anaesthesiol 2002;19:276-82.

El Azab SR, Rosseel PM, Lange JJ de, Groeneveld AB, Strik R de, Wijk EM van, Scheffer GJ. Dexamethasone decreases the pro- to anti-inflammatory cytokine ratio during cardiac surgery.

Br J Anaesth 2002;88:496-501.

Fleischmann KE, Hunink MGM, Kuntz KM, Douglas PS. Exercise echocardiography or exercise SPECT imaging? A meta-analysis of diagnostic test performance. (Letter)

J Nucl Cardiol 2002;9:133-4 .

Gabeler EE, Hillegersberg R van, Statius Van Eps RG, Sluiter W, Gussenhoven EJ, Mulder P, Urk H van. A comparison of balloon injury models of endovascular lesions in rat arteries.

BMC Cardiovasc Disord 2002;2:16.

Gabeler EE, Hillegersberg R van, Statius van Eps RG, Sluiter W, Mulder P, Urk H van. Endovascular photodynamic therapy with aminolaevulinic acid prevents balloon induced intimal hyperplasia and constrictive remodelling.

Eur J Vasc Endovasc Surg 2002;24:322-31.

Gaspoz JM, Coxson PG, Goldman PA, Williams LW, Kuntz KM, Hunink MGM, Goldman L. Cost-effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease.

N Eng J Med 2002;346:1800-6.

Graaf EJ de, Doornebosch PG, Stassen LP, Debets JM, Tetteroo GW, Hop WCJ. Transanal endoscopic microsurgery for rectal cancer.

Eur J Cancer 2002;38 904-10.

Groenewoud GC, Jong NW de, Oorschot-van Nes AJ van, Vermeulen AM, Toorenenbergen AW van, Mulder PG, Burdorf A, Groot H de, Gerth van Wijk R. Prevalence of occupational allergy to bell pepper pollen in greenhouses in the Netherlands.

Clin Exp Allergy 2002;32:434-40.

Groof F de, Joosten KF, Janssen JA, Kleijn ED de, Hazelzet JA, Hop WCJ, Uitterlinden P,   Doorn J van, Hokken-Koelega AC. Acute stress response in children with meningococcal sepsis: important differences in the   growth hormone/insulin-like growth factor I axis between nonsurvivors and survivors.

J Clin Endocrinol Metab 2002;87:3118-24.

Gudlaugsdottir S, Verschuren W, Dees J, Stijnen T, Wilson J. Hypertension is frequently present in patients with reflux esophagitis or Barrett's esophagus but not in those with non-ulcer dyspepsia.

Eur J Intern Med 2002;13:369.

Gudlaugsdottir S, Dekken H van, Stijnen T, Wilson JH. Prolonged use of protom pump inhibitors, CagA status, and the outcome of Helicobacter pyloris gastritis.

J Clin Gastroenterol 2002;34:536-40.

Harst E van der, Herder WW de, Krijger RR de, Bruining HA, Bonjer HJ, Lamberts SW, Meiracker AH van den, Stijnen T, Boomsma F. The value of plasma markers for the clinical behaviour of haeochromocytomas.

Eur J Endocrinol 2002;147:85-94.

Hinnen P, Rooij F de, Hop W, Edixhoven A, Dekken H van, Wilson J, Siersema P. Timing of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of patients with Barrett's

oesophagus.  

J Photochem Photobiol B 2002;68:8-14.

Hofhuis W, Huysman MW, Wiel EC van der, Holland WP, Hop WC, Brinkhorst G, Jongste JC de, Merkus PJ. Worsening of V'maxFRC in infants with chronic lung disease in the first year of life: a more favorable outcome after high-frequency oscillation ventilation.  

Am J Respir Crit Care Med 2002;166:1539-43.

Holten J van, Kunz P, Mulder PG, Pattynama PM, Lamb HJ, Dijk LC van. MR-velocity mapping in vascular stents to assess peak systolic velocity. In vitro comparison of various stent designs made of stainless steel and nitinol.

MAGMA 2002;1:52-7.

Hoogerbrugge N, Groot E de, Heide LHM de, Ridder MAJ de, Birkenhäger JC, Stijnen T, Jansen H. Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study).
Neth J Med 2002;60:354-61 .

Houwelingen JC van, Arends LR, Stijnen T. Advanced methods in meta-analysis: multivariate approach and meta-regression.
Stat Med 2002;21:589-624.

Inciardi JF, Stijnen T, McMahon K. Using correspondence analysis in pharmacy practice.

Am J Health Syst Pharm 2002;59:968-72.

Incrocci L, Hop WCJ, Wijnmaalen A, Slob AK. Treatment outcome, body image, and sexual functioning after orchiectomy and radiotherapy for stage I-II testicular seminoma.

Int J Radiat Oncol Biol Phys 2002;53:1165-73.

Jaquet JB, Kalmijn S, Kuypers PD, Hofman A, Passchier J, Hovius SE. Early psychological stress after forearm nerve injuries: a predictor for long-term functional outcome and return to productivity.

Ann Plast Surg 2002;49:82-90.

Jansen AJG, Schipperus MR, Hop WCJ, Beckwers EAM, Boekhorst PAW te, Sonneveld P, Rhenen DJ van. Temple study: transfusion effects in myelodysplastic patients; limiting exposure.

NVB Bulletin 2002;3:2-5.

Kaay DC van der, Kleijn ED de, Rijke YB de, Hop WCJ, Groot R de, Hazelzet JA. Procalcitonin as a prognostic marker in meningococcal disease.

Intensive Care Med 2002;28:1606-12 .

Klerk G de, Hop WC, Hoog M de, Joosten KF. Serial measurements of energy expenditure in critically ill children: useful in optimizing nutritional therapy?

Intensive Care Med 2002;28:1781-5.

Kros JM, Bagdi EK, Zheng P, Hop WCJ, Driesse MJ, Krenacs L, Dinjens WN. Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma.  

J Neurosurg 2002;97:1390-6.

Kuijf MM, Kwekkeboom J, Kuijpers MA, Willems M, Zondervan PE, Niesters HG, Hop WCJ, Hack CE, Paavonen T, Hockerstedt K, Tilanus HW, Lautenschlager I, Metselaar HJ. Granzyme expression in fine-needle aspirates from liver allografts is increased during acute rejection.  

Liver Transpl 2002;8:952-6.

Laudy JA, Tibboel D, Robben SG, Krijger RR de, Ridder MA de, Wladimiroff JW. Prenatal prediction of pulmonary hypoplasia: clinical, biometric, and Doppler velocity correlates.

Pediatrics 2002;109:250-8.

Lequin MH,   Sluis M van der,   Rijn RR van, Hop WC, Huevel-Eibrink MM van den, Muinck Keizer-Schrama SM de,   Kuijk C van. Bone mineral assessment with tibial ultrasonometry and dual-energy X-ray absorptiometry in long-term survivors of   acute lymphoblastic leukemia in childhood.

J Clin Densitom 2002;5:167-73.

Lind MY, Hazebroek EJ, Hop WCJ, Weimar W, Bonjer JH, IJzermans JN. Right-sided laparoscopic live-donor nephrectomy.

Transplantation 2002;74:1045-8.

Meurs JC van, Feron E, Ruyven R van, Mulder P, Veckeneer M. Postoperative laser coagulation as retinopexy in patients with rhegmatogenous retinal detachment treated with scleral buckling surgery: a prospective clinical study.

Retina 2002;22:733-9.

Meijer RJ, Postma DS, Kauffman HF, Arends LR, Koeter GH, Kerstjens HA. Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma.

Clin Exp Allergy 2002;32:1096-1103 .

Middelkamp Hup MA, Heide R, Tank B, Mulder PG, Oranje AP. Comparison of mastocytosis with onset in children and adults.

J Eur Acad Dermatol Venereol 2002;16:115-20.

Nederkoorn PJ, Mali WP, Eikelboom BC, Elgersma OEH, Buskens E, Hunink MGM, Kappelle J, Buijs PC, Wüst AF, Lugt A van der, Graaf Y van der. Pre-operative diagnosis of carotid artery stenosis: Accuracy of non-invasive testing.

Stroke 2002;33:2003-8.

Oranje AP, Mulder PG, Heide R, Tank B, Riezebos P, Toorenenbergen AW van. Urinary N-methylhistamine as an indicator of bone marrow involvement in mastocytosis.

Clin Exp Dermatol 2002;27:502-6.

Os-Bossagh P van, Pols T, Hop WCJ, Nelemans T, Erdmann W, Drogendijk AC, Bohnen AM. Questionnaire as diagnostic tool in chronic pelvic pain (CPP): a pilot study.

Eur J Obstet Gynecol Reprod Biol 2002;103:173-8.

Pareren YK van, Muinck Keizer-Schrama SM de, Stijnen T, Sas TC, Drop SL. Effect of discontinuation of long-term growth hormone treatment on carbohydrate metabolism and risk factors for cardiovascular disease in girls with turner syndrome.

J Clin Endocrinol Metab 2002;87:5442-8.

Rave S de, Tilanus HW, Linden J van der, Man RA de, Berg B van der, Hop WCJ, IJzermans JM, Zondervan   PE, Metselaar HJ. The importance of orthotopic liver transplantation in acute hepatic failure.

Transpl Int 2002;15:29-33.

Rossum AM van, Dieleman JP, Fraaij PL, Cransberg K, Hartwig NG, Burger DM, Gyssens IC, Groot R de. Persistent sterile leucyturia is associated with impaired renal function in human immunodeficiency virus type 1-infected children treated with indinavir.

Pediatrics 2002;110:19-26.

Rossum AM van, Geelen SP, Hartwig NG, Wolfs TF, Weemaes CM, Scherpbier HJ, Lochem EG van, Hop WCJ, Schutten M, Osterhaus AD, Burger DM, Groot R de. Results of 2 years of treatment with protease-inhibitor-containing antiretroviral therapy in Dutch children infected with human immunodeficiency virus type 1.

Clin Infect Dis 2002;34:1008-16.

Sluis IM van der, Hop WCJ, Leeuwen JP van, Pols HA, Muinck Keizer-Schrama SM de. A cross-sectional study on biochemical parameters of bone turnover and vitamin d metabolites in healthy Dutch children and young adults.

Horm Res 2002;57:170-9.

Sluis IM van der, Ridder MA de, Boot AM, Krenning EP, Muinck Keizer-Schrama SM de. Reference data for bone density and body composition measured with dual energy x-ray absorptiometry in white children and young adults.

Arch Dis Child 2002;87:341-7.

Sluis IM van der, Boot AM, Hop WCJ, Rijke YB de, Krenning EP, Muinck Keizer-Schrama   SM de. Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study.   

Horm Res 2002;58:207-14.

Storosum JG, Elferink AJA, Zwieten BJ van, Strik R van, Hoogendijk WJG, Broekmans AW. Amisulpride: Is there a treatment for negative symptoms in schizophrenia patients?

Schizophrenia Bulletin 2002;28:193-201.

Swank DJ, Erp WF van, Repelaer Van Driel OJ, Hop WCJ, Bonjer HJ, Jeekel J. Complications and feasibility of laparoscopic adhesiolysis in patients with chronic abdominal pain.

Surg Endosc 2002;16:1468-73.

Tran K, Eijck C van, Di Carlo V, Hop WC, Zerbi A, Balzano G, Jeekel H. Occlusion of the pancreatic duct versus pancreaticojejunostomy: a prospective randomized trial.  

Ann Surg 2002;236:422-8.

Verhoeven GT, Hegmans JP, Mulder PG, Bogaard JM, Hoogsteden HC, Prins JB. Effects of fluticasone propionate in COPD patients with bronchial hyperresponsiveness.

Thorax 2002;57:694-700 .

Visser MJ, Postma DS, Brand PLP, Arends LR, Duiverman EJ, Kauffman HF. Influence of different dosage schedules of inhaled fluticasone propionate on peripheral blood cytokine concentrations in childhood asthma.

Clin Exp Allergy 2002;32:1497-1503.

Vreugdenhil HJ, Slijper FM, Mulder PG, Weisglas-Kuperus N. Effects of perinatal exposure to PCBs and dioxins on play behavior in Dutch children at school age.

Environ Health Perspect 2002;110:A593-8.

Vreugdenhil HJ, Lanting CI, Mulder PG, Boersma ER, Weisglas-Kuperus N. Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age.

J Pediatr 2002;140:48-56 .

Vries SO de, Visser K, Vries JA de, Wong JB, Donaldson MC, Hunink MGM. Intermittent claudication: cost-effectiveness of revascularization versus exercise therapy .

Radiology 2002;222:25-36 .

Vrijland WW,   Tol MP van den, Luijendijk RW, Hop WCJ, Busschbach JJ, Lange   DC de, Geldere D van Rottier AB, Vegt PA, IJzermans JN, Jeekel J. Randomized clinical trial of non-mesh versus mesh repair of primary inguinal hernia.

Br J Surg 2002;89:293-7.

Vrijland WW, Tseng LN, Eijkman HJ, Hop WCJ, Jakimowicz JJ, Leguit P, Stassen LP, Swank DJ, Haverlag R, Bonjer HJ, Jeekel H. Fewer intraperitoneal adhesions with use of hyaluronic acid-carboxymethylcellulose   membrane: A randomized clinical trial.

Ann Surg 2002;235:193-9.

Warle MC, Farhan A, Metselaar HJ, Hop WCJ, Perrey C, Zondervan PE, Kap M, Rave S de, Kwekkeboom J, IJzermans JN, Tilanus HW, Pravica V, Hutchinson IV, Bouma GJ. Cytokine gene polymorphisms and acute human liver graft rejection.

Liver Transpl 2002;8:603-11.

Wiegersma PA, Hofman A, Zielhuis GA. Evaluation of community-wide interventions: the ecologic case-referent study design.

Eur J Epidemiol 2001;17:551-7.

Wildt SN de, Kearns GL, Hop WCJ, Murry DJ, Abdel-Rahman SM, Anker JN van den. Pharmacokinetics and metabolism of oral midazolam in preterm infants.

Br J Clin Pharmacol 2002;53:390-2.

Willemse MJ, Seriu T, Hettinger K, D'Aniello E, Hop WCJ, Panzer-Grumayer ER, Biondi A, Schrappe M, Kamps WA, Masera G, Gadner H, Riehm H, Bartram CR, Dongen JJ van. Detection of minimal residual disease identifies differences in treatment response between T-ALL and precursor B-ALL.

Blood 2002;99:4386-93.

Wolters LM, Hansen BE, Niesters HG, DeHertogh D, Man RA de. Corrigendum to "Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B" [J Hepatol 37 (2002) 137-144].

J Hepatol 2002;37:708.

Wolters LM, Hansen BE, Niesters HG, Man RA de. Viral dynamics in chronic hepatitis B patients treated with lamivudine, lamivudine-famciclovir or lamivudine-ganciclovir.

Eur J Gastroenterol Hepatol 2002;14:1007-11.

Wolters LM, Hansen BE, Niesters HG, Levi-Drummer RS, Neumann AU, Schalm SW, Man RA de. The influence of baseline characteristics on viral dynamic parameters in chronic hepatitis B patients treated with lamivudine.

J Hepatol 2002;37:253-8.

Wolters LM, Hansen BE, Niesters HG, DeHertogh D, Man RA de. Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B.

J Hepatol 2002;37:137-44 .

Wolters LM, Hansen BE, Niesters HG, Zeuzem S, Schalm SW, Man RA de. Viral dynamics in chronic hepatitis B patients during lamivudine therapy.

Liver 2002;22:121-6.

Wolters LM, Niesters HG, Hansen BE, Ende ME van der, Kroon FP, Richter C, Brinkman K, Meenhorst PL, Man RA de. Development of hepatitis B virus resistance for lamivudine in chronic hepatitis B patients co-infected with the human immunodeficiency virus in a Dutch cohort.

J Clin Virol 2002;24:173-81.

Zee AH, Stricker BH, Klungel OH, Kastelein JJ, Hofman A, Leufkens HG, Duijn CM van, Boer AD. Adherence to and dosing of statins differs according to apolipoprotein E-genotypes.
Br J Clin Pharmacol 2002;54:559.

National scientific publications

Kooiman ELM, Dieleman JP, Gyssens IC, Nieuwkerk PT, De Marie S, Ende ME van der.
Therapietrouw onder HIV-geïnfecteerden in Rotterdam: onafhankelijk van nationaliteit slechter bij heteroseksueel besmette patiënten, intraveneuze druggebruikers, negroïde en Latijns-Amerikaanse patiënten.

Ned Tijdschr Geneeskd 2002;146:1183-7.

Moll van Charante A, Mulder P, Leijten J.
Bedrijfsarts kan langdurig verzuim voorspellen.

Arbeidsomstandigheden 2002;78:32-5.

Moll van Charante A, Mulder P. Woonstreek en werk.
Determinanten van duurzame reïntegratie.

Reïntegratie 2002;2:29-33.

Moll van Charante A, Mulder P. Wie vervangt de bedrijfsarts?

Reïntegratie 2002;2:30-4.